| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367970 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
We examined neuroprotective effects of naturally occurring biflavonoids on oxidative stress-induced and amyloid β peptide-induced cell death in neuronal cells. Among the nine biflavonoids tested, amentoflavone, ginkgetin, and isoginkgetin exhibited strong neuroprotection against cytotoxic insults induced by oxidative stress and amyloid β, suggesting their therapeutic potential against neurodegenerative diseases, including ischemic stroke and Alzheimer’s disease.
Graphical abstractWe examined the neuroprotective effects of naturally occurring biflavonoids on oxidative stress-induced and amyloid β peptide-induced cell death in neuronal cells. Among the nine biflavonoids tested, amentoflavone, ginkgetin, and isoginkgetin exhibited strong neuroprotection against cytotoxic insults induced by oxidative stress and amyloid β, suggesting their therapeutic potential against neurodegenerative diseases, including ischemic stroke and Alzheimer’s disease.
