Glycosidase inhibition by 1-glycosyl-4-phenyl triazoles

1-Glycosyl-4-phenyl triazoles have been prepared via a copper-mediated [3 + 2] cycloaddition of glycosyl azides with phenylacetylene. These triazoles have been evaluated for their ability to inhibit the enzymatic activity of glycosidases.

Graphical abstractGlycosyl triazoles have been prepared by a ‘click’ reaction between glycosyl azides and alkynes. These triazoles are inhibitors of β-galactosidases from Escherichia coli and bovine liver.Figure optionsDownload full-size imageDownload as PowerPoint slide