| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1367981 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Various heterocyclic hetero-methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A study of their structure–activity relationship (SAR) related to caspase-1, -3, -6, and -8 is reported. Their efficacy in a cellular model of cell death is also discussed. Potent broad-spectrum caspase inhibitors have been identified.
Graphical abstractVarious heterocyclic hetero-methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A study of their structure–activity relationship (SAR) related to caspase-1, -3, -6, and -8 is reported. Their efficacy in a cellular model of cell death is also discussed. Potent broad-spectrum caspase inhibitors have been identified.Figure optionsDownload full-size imageDownload as PowerPoint slide
