Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1368502 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
Protein prenylation is a type of post-translational modification that aids certain proteins in localizing to the plasma member where they activate cell signaling. To better understand the isoprenoid requirements and differences of FTase and GGTase-I, a series of saturated geranylgeranyl diphosphate analogs were synthesized and screened against both mammalian FTase and GGTase-I. Of our library of compounds, several analogs proved to be substrates of GGTase-I, with 11d having a krel = 0.95 when compared to GGPP (krel = 1.0).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kayla J. Temple, Elia N. Wright, Carol A. Fierke, Richard A. Gibbs,