| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368520 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
•Four new brominated indole related alkaloids were isolated from Laurencia similis.•1 was the first naturally occurring 3-benzyl-indole derivative.•2 was the first natural 1,3-dihydro-indole-2-one with 2-isopropylidene group.•3 and 4 were the first carbazole and 2-carbonylamino-benzoate from the genus Laurencia.•1 showed the most potent antibacterial activity against seven bacterial strains.
Four new minor brominated indole related alkaloids (one indoles, 1, one 1,3-dihydro-indole-2-one, 2, one carbazole, 3, and one 2-carbonylamino-benzoate, 4) were isolated and identified from Laurencia similis by extensive chromatographic and spectrometric methods. Among them, 1 and 2 were the first example of naturally occurring indole with 3-benzyl group and 1,3-dihydro-indole-2-one with 2-isopropylidene group, respectively, whereas 3 and 4 were the first carbazole alkaloids and 2-carbonylamino-benzoate, respectively, isolated from the genus Laurencia. Moreover, 1 showed the most potent antibacterial activity against seven bacterial strains with MIC values ranging from 2 to 8 μg/mL.
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