Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1368534 | Bioorganic & Medicinal Chemistry Letters | 2016 | 6 Pages |
The synthesis of various substituted triazole–indenoisoquinoline hybrids was performed based on a CuI-catalyzed 1,3-cycloaddition between propargyl-substituted derivatives and the azide-containing indenoisoquinoline. Besides, a variety of N-(alkyl)propargylindenoisoquinolines was used as substrates for the construction of triazole–indenoisoquinoline–AZT conjugated via a click chemistry-mediated coupling with 3′-azido-3′-deoxythymidine (AZT). Thus, twenty three new indenoisoquinoline-substituted triazole hybrids were successfully prepared and evaluated as cytotoxic agents, revealing an interesting anticancer activity of four triazole linker–indenoisoquinoline–AZT hybrids in KB and HepG2 cancer cell lines.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide