| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368579 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
In search for novel lead compounds as γ-secretase inhibitors, analogs of aminopyrido[2,3-d]pyrimidin-7-ones (I) were synthesized and evaluated for inhibitory effects on amyloid-β-peptide production and cleavage of the Notch1 receptor mediated by γ-secretase. Selected pyridopyrimidines, such as 1, 8, 9, 10, 11 and 16 are γ-secretase inhibitors that did not have an effect on Notch1 receptor processing.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jing Zhang, Dai Lu, Han-Xun Wei, Yongli Gu, Dennis J. Selkoe, Michael S. Wolfe, Corinne E. Augelli-Szafran,