Synthesis, antimycobacterial and antibacterial activity of 1-(6-amino-3,5-difluoropyridin-2-yl)fluoroquinolone derivatives containing an oxime functional moiety

A series of novel 1-(6-amino-3,5-difluoropyridin-2-yl)fluoroquinolone derivatives containing an oxime functional moiety were synthesized and evaluated for their biological activity. Our results reveal that compounds 9a–9c have considerable activity against both of MTB H37Rv ATCC 27294 (MICs: 3.81–7.13 μg/mL) and methicillin-sensitive Staphylococcus aureus strains (MICs: <0.008–0.5 μg/mL).

Graphical abstractA series of novel 1-(6-amino-3,5-difluoropyridin-2-yl)fluoroquinolone derivatives containing an oxime functional moiety were synthesized and evaluated for their biological activity. Our results reveal that compounds 9a–9c have considerable activity against MTB H37Rv ATCC 27294 (MICs: 3.81–7.13 μg/mL) and methicillin-sensitive Staphylococcus aureus strains (MICs: <0.008–0.5 μg/mL).Figure optionsDownload full-size imageDownload as PowerPoint slide