| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368623 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
The discovery of a new class of nonprostanoid prostaglandin I2 receptor (IP receptor) agonists is reported. Among them, the unique piperidine derivative 31b (2-((1-(2-(N-(4-tolyl)benzamido)ethyl)piperidin-4-yl)oxy)acetic acid) was a good IP receptor agonist and was 50-fold more selective for the human IP receptor than for other human prostanoid receptors. This compound showed good pharmacokinetic properties in dog.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ryoji Hayashi, Hideki Sakagami, Masakazu Koiwa, Hiroaki Ito, Mitsuko Miyamoto, Masafumi Isogaya,