| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368661 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Based on a screening lead from a yeast-based assay to identify Src family kinase inhibitors, a series of 4-anilino-7-thienyl-3-quinolinecarbonitriles was prepared. When the thiophene ring was substituted with a water-solubilizing group in a 2,5-, 3,5- or 2,4-pattern, potent inhibition of Src kinase activity was observed.
The preparation and Src kinase inhibitory activity of a series of 4-anilino-7-thienyl-3-quinolinecarbonitriles is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Diane H. Boschelli, Daniel Y. Wang, Fei Ye, Ayako Yamashita, Nan Zhang, Dennis Powell, Jennifer Weber, Frank Boschelli,