| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368702 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
Four new farnesyl phenolic compounds, ganosinensols A–D (1–4) were isolated from the 95% EtOH extract of the fruiting bodies of Ganoderma sinense. Two pairs of enantiomers, 1/2, and 3/4 were isolated by HPLC using a Daicel Chiralpak IE column. Their structures were elucidated from extensive spectroscopic analyses and comparison with literature data. The absolute configurations of 1–4 were assigned by ECD spectra. All of these isolated compounds showed potent inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages, with IC50 values from 1.15 to 2.26 μM.
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Related Topics
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Organic Chemistry
Authors
Meng Wang, Fei Wang, Feng Xu, Li-Qin Ding, Qian Zhang, Hui-Xiang Li, Feng Zhao, Li-Qing Wang, Li-Han Zhu, Li-Xia Chen, Feng Qiu,