Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1368704 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
Bioactivity-guided fractionation of the MeOH extract from the roots of Euphorbia kansui resulted in the isolation of two new jatrophane-type diterpenoids, kanesulones A (1) and B (2), together with six known jatrophane-type diterpenoids (3–8) and ten known ingenane-type diterpenoids (9–18). Their chemical structures were elucidated on the basis of spectroscopic data interpretation, especially 1D and 2D NMR such as HMQC, HMBC, COSY and NOESY, and HRESIMS data as well as CD analysis. Compounds 1–8 and 11–18 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values ranging from 0.7 to 46.5 μM in RAW 264.7 macrophages.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jin Woo Lee, Qinghao Jin, Hari Jang, Dongho Lee, Sang Bae Han, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang,