| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368721 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highly potent, orally active Notum Pectinacetylesterase inhibitors were identified.
Graphical abstractA group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highly potent, orally active Notum Pectinacetylesterase inhibitors were identified.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
James E. Tarver Jr., Praveen K. Pabba, Joseph Barbosa, Qiang Han, Michael W. Gardyan, Robert Brommage, Andrea Y. Thompson, James M. Schmidt, Alan G.E. Wilson, Wei He, Victoria K. Lombardo, Kenneth G. Carson,