Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1368726 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Transglycosylation reactions biocatalyzed by the native arabinofuranosidase Araf51 and using d-galactosyl, d-fucosyl and 6-deoxy-6-fluoro-d-galactosyl derivatives as donors and acceptors provided di-to pentahexofuranosides. The immunostimulatory potency of these compounds, and more especially their ability to induce production of TNF-α, was evaluated on the murine macrophage cell line, Raw 264.7. The results obtained showed concentration-dependent and most importantly, structure-dependent responses. Interestingly, oligoarabinofuranosides belonging to the oligopentafuranoside family displayed concentration-, chain length and aglycon-dependent bioactivities irrespective of their fine chemical variations. Thus, neo-oligofuranosides in d-Galf series, as well as their d-Fucf and 6-fluorinated counterparts are indeed potential sources of immunostimulating agents.
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