| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368727 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
This Letter describes an efficient ring-closing metathesis approach to 2-chloro-4-amino-pyrimido[4,5-c]azepines and 2-chloro-4-amino-pyrimido[4,5-c]oxepines. These chlorides were applied to the synthesis of several potent γ-secretase modulators (GSMs).
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators](/preview/png/1368727.png "First Page Preview: Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators")
Authors
Yong-Jin Wu, Yunhui Zhang, Jeremy H. Toyn, John E. Macor, Lorin A. Thompson,