Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1368737 | Bioorganic & Medicinal Chemistry Letters | 2016 | 6 Pages |
Abstract
One new macrolactam derivative, nivelactam (1) and one new polyenoic acid derivative, niveamide (2), along with two other known 20-atom macrolactams (3 and 4) were isolated from the fermentation broth of Streptomyces niveus, which obtained from the forest soil in northeastern China. The structures of 1 and 2 were elucidated on the basis of HRESIMS, IR, and NMR spectroscopic data analyses. Compound 1 was proposed as an intramolecular [4+6]-cycloaddition product of 3 by S. niveus, and displayed moderate cytotoxic activity against a panel of human tumor cell lines in vitro, with IC50 values ranging from 3.76 ± 0.58 to 15.02 ± 2.81 μM.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Liya Li, Yaping Cai, Yi Jiang, Jiang Liu, Jian Ma, Chunhui Yuan, Yu Mu, Li Han, Xueshi Huang,