Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1368778 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
Ten ent-abietane diterpenoids (1–10), including four new (1–4) and six known ones (5–10) were isolated from the roots of Euphorbia ebracteolata. Their structures were determined by 1D, 2D NMR, and HRESIMS. Compounds 2, 4, and 7 exhibited significant inhibitory activities on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 0.69, 1.97, and 0.88 μM, respectively. A primary structure–activity relationship was also discussed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhi-guo Liu, Zhan-lin Li, Da-hong Li, Ning Li, Jiao Bai, Feng Zhao, Da-li Meng, Hui-ming Hua,