| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368793 | Bioorganic & Medicinal Chemistry Letters | 2016 | 6 Pages |
Abstract
A series of β-boswellic acid derivatives were synthesized and evaluated for anticancer activity. One of the lead analog 4f displayed significant anticancer activity against a panel of cancer cells as well as substantially inhibited colony formation in HCT-116 cells. Furthermore, 4f was found to be a potent inducer of apoptosis confirmed by loss of mitochondrial membrane potential, DAPI staining, Western blotting and ROS generation.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Arvind Kumar, Arem Qayum, Parduman Raj Sharma, Shashank Kumar Singh, Bhahwal Ali Shah,