| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368798 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
A novel series of EP4 antagonists, based on a quinoline scaffold, has been discovered. Medicinal chemistry efforts to optimize the potency of the initial hit are described. A highly potent compound in a clinically relevant human whole blood assay was identified. Selectivity and pharmacokinetic profiles of this compound are discussed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maria-Jesus Blanco, Tatiana Vetman, Srinivasan Chandrasekhar, Matthew J. Fisher, Anita Harvey, Daniel Mudra, Xu-Shan Wang, Xiao-Peng Yu, Matthew A. Schiffler, Alan M. Warshawsky,