| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368807 | Bioorganic & Medicinal Chemistry Letters | 2016 | 6 Pages |
Abstract
Conditions for the metathesis of alkenes in the convergent synthesis of HDAC inhibitors have been improved by continuous catalyst flow injection in the reaction media. Intermediate and target compounds obtained were tested for their ability to induce HDAC inhibition and tubulin acetylation, revealing the key role of the tert-butyloxycarbonyl (BOC) group for more HDAC6 selectivity. Molecular modelling added rationale for this BOC effect.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vincent Zwick, Alessandra Nurisso, Claudia Simões-Pires, Samuel Bouchet, Nadine Martinet, Attila Lehotzky, Judit Ovadi, Muriel Cuendet, Christophe Blanquart, Philippe Bertrand,