| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368820 | Bioorganic & Medicinal Chemistry Letters | 2016 | 7 Pages |
Abstract
Demand remains for new inhibitors of HIV-1 replication and the inhibition of HIV-1 entry is an extremely attractive therapeutic approach. Using field-based bioisosteric replacements, we have further extended the chemotypes available for development in the HIV-1 entry inhibitor class. Moreover, using field-based disparity analysis of the compounds, 3D structure–activity relationships were derived that will be useful in the further development of these inhibitors towards clinical utility.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Marina Tuyishime, Rae Lawrence, Simon Cocklin,