| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368821 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Milena Simic, Nikola Paunovic, Ivan Boric, Jelena Randjelovic, Sandra Vojnovic, Jasmina Nikodinovic-Runic, Marina Pekmezovic, Vladimir Savic,