Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1368834 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
Alzheimer’s disease is a persistent neurodegenerative disorder of elderly characterized clinically by irreversible loss of memory due to accumulation of amyloid beta peptides within the amyloid plaques. We report the parallel synthesis and screening results of diverse substituted di-thiazole piperazine benzamides. A new compound TPI-1917-49 was identified as a promising amyloid reducing agent by lowering the levels of Aβ at least in two cell types and in vivo.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hongjie Wang, Ruizhi Wang, Madepalli K. Lakshmana, Adel Nefzi,