| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368840 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
An efficient, diversity oriented synthesis of homoisoprenoid α-monofluorophosphonates utilizing electrophilic fluorination is presented along with their activity as inhibitors of PPAPDC2 family integral membrane lipid phosphatases. These novel phosphatase-resistant analogues of isoprenoid monophosphates are a platform for further structure–activity relationship studies and provide access to other isoprenoid family members where the phosphate ester oxygen is replaced by a α-monofluoromethylene moiety.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thangaiah Subramanian, Hongmei Ren, Karunai Leela Subramanian, Manjula Sunkara, Fredrick O. Onono, Andrew J. Morris, H. Peter Spielmann,