Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1368865 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway by PI3K/mTOR dual inhibitors provides a promising new approach to the treatment of cancers. In this Letter, we identified structurally novel and potent PI3K/mTOR dual inhibitors from a series of 2-amino-4-methylpyrido[2,3-d]pyrimidine derivatives. Their synthesis and structure–activity relationships are reported.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fangbin Han, Songwen Lin, Peng Liu, Jing Tao, Chongqin Yi, Heng Xu,