| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1368876 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
The synthesis and pharmacological data of some new and potent hydrophilic 5-HT4 receptor antagonists are described. Propanediol derivative 25 was identified as a potent antagonist with low affinity for the hERG potassium channel and promising pharmacokinetics.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bjarne Brudeli, Mirusha Navaratnarajah, Kjetil Wessel Andressen, Ornella Manfra, Lise Román Moltzau, Nils Olav Nilsen, Finn Olav Levy, Jo Klaveness,