| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369034 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
A series of pro-nucleotide phosphoramidates and phosphorodiamidates of the antiviral lead compound 3′-deoxy-3′-fluorothymidine (FLT) have been designed and synthesized. In vitro antiretroviral and cytostatic studies revealed potent (sub-micromolar) inhibition of HIV-1 and HIV-2 replication, with retention of activity in thymidine kinase-negative cell models, as predicted by the ProTide concept.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Winnie Velanguparackel, Nadège Hamon, Jan Balzarini, Christopher McGuigan, Andrew D. Westwell,