| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369036 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
By considering published structural information we have designed high throughput biaryl lipophilic acid arrays leveraging facile chemistry to expedite their synthesis. We rapidly identified multiple hits which were of suitable IP agonist potency. These relatively simple and strategically undecorated molecules present an ideal opportunity for optimization towards our target candidate profile.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stephen C. McKeown, Steven J. Charlton, Brian Cox, Helen Fitch, Christopher D. Howson, Catherine Leblanc, Arndt Meyer, Elizabeth M. Rosethorne, Emily Stanley,