| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369042 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
We describe two series of Syk inhibitors which potently abrogate Syk kinase function in enzymatic assays, cellular assays and in primary cells in the presence of blood. Introduction of a 7-aminoindole substituent led to derivatives with good kinase selectivity and little or no hERG channel inhibition (3b, 10c).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gebhard Thoma, Joachim Blanz, Peter Bühlmayer, Peter Drückes, Matthias Kittelmann, Alexander B. Smith, Maurice van Eis, Eric Vangrevelinghe, Hans-Günter Zerwes, Jianwei (John) Che, Xiaohui He, Yunho Jin, Christian C. Lee, Pierre-Yves Michellys,