| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369057 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
PNA sequences modified with charged side chains were evaluated for base-pairing sequence selectivity under physiological conditions. PNA having negatively charged aspartic acid side chains shows higher selectivity with RNA, while PNA having positively charged lysine side chains shows higher selectivity with DNA. These observations provide insight into the binding selectivity of modified PNA in antisense and antigene applications.
Graphical abstractSequence selectivity of γ-modified PNA was investigated at physiological ionic strength. Changing the structure and charge of the PNA side chains provides differential selectivity for DNA and RNA.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
N. Tilani S. De Costa, Jennifer M. Heemstra,