| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369060 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
Non-covalent (NP-1/3) and covalent (NP-A-1/3) pro-apoptotic SPION-Smac mimetic nano-conjugates antitumor agents are reported. The solution synthesis of key Smac mimetics, their support onto SPIONs through non-covalent adsorption (NP-1/3) or APTES-mediated covalent binding (NP-A-1/3), the analytical characterization of SPION-Smac mimetic conjugates, their target affinity in cell-free assays, and their cytotoxicity against tumor cells are thoroughly described.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pierfausto Seneci, Mattia Rizzi, Luigi Ballabio, Daniele Lecis, Annalisa Conti, Claudio Carrara, Emanuela Licandro,