| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369084 | Bioorganic & Medicinal Chemistry Letters | 2015 | 5 Pages |
Abstract
Small molecule modulators of GPR88 activity (agonists, antagonists, or modulators) are of interest as potential agents for the treatment of a variety of psychiatric disorders including schizophrenia. A series of phenylglycinol and phenylamine analogs have been prepared and evaluated for their GPR88 agonist activity and pharmacokinetic (PK) properties.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Carolyn D. Dzierba, Yingzhi Bi, Bireshwar Dasgupta, Richard A. Hartz, Vijay Ahuja, Giovanni Cianchetta, Godwin Kumi, Li Dong, Saadat Aleem, Cynthia Fink, Yudith Garcia, Michael Green, Jianxin Han, Soojin Kwon, Ying Qiao, Jiancheng Wang, Yulian Zhang,