Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369091 | Bioorganic & Medicinal Chemistry Letters | 2015 | 4 Pages |
Abstract
The structure–activity relationships of a novel series of sphingosine-1-phosphate receptor antagonists have been examined in detail. The initial hit compound 1 was modified through synthesis to improve its S1P2 activity. The synthesis of a series of analogs revealed that 1,3-bis(aryloxy)benzene derivatives, as represented by 22, are potent and selective S1P2 antagonists.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kensuke Kusumi, Koji Shinozaki, Toshiya Kanaji, Haruto Kurata, Atsushi Naganawa, Kazuhiro Otsuki, Takeshi Matsushita, Tetsuya Sekiguchi, Akito Kakuuchi, Takuya Seko,