| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369094 | Bioorganic & Medicinal Chemistry Letters | 2015 | 6 Pages |
Abstract
A series of indole carboxylic acid derivatives were designed and synthesized. Their anti-type 2 diabetes activity was evaluated in HepG2 cell and db/db mice. The results showed that compounds 8c, 17a, 17b, 15a and 15b could significantly increase glucose consumption in HepG2 cell. Furthermore, compound 8c was able to lower the blood glucose level and induce less weight gain in db/db mice.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lingling Fan, Jianta Wang, Xiao Ma, Wan Xiao, Zhiyan Li, Gang Zhong, Lei Tang, Haoshu Wu,