Article ID Journal Published Year Pages File Type
1369107 Bioorganic & Medicinal Chemistry Letters 2015 4 Pages PDF
Abstract

Twenty-four derivatives of erythrocentaurin (ET) were synthesized and evaluated for their anti-HBV activities on HepG 2.2.15 cell line in vitro. Eight compounds 1, 2, 5, 8, 9, 1e, 1k, and 1m increased activity against HBV DNA replication with the SI values higher than 11. In particular, derivatives 1e and 1k exhibited the most potent inhibition on HBV DNA replication with the IC50 values of 0.026 mM (SI >70.8) and 0.045 mM (SI >36.0), respectively. The primary structure–activity relationships (SARs) of ET derivatives were summarized for exploring potent anti-HBV agents.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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