Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369107 | Bioorganic & Medicinal Chemistry Letters | 2015 | 4 Pages |
Abstract
Twenty-four derivatives of erythrocentaurin (ET) were synthesized and evaluated for their anti-HBV activities on HepG 2.2.15 cell line in vitro. Eight compounds 1, 2, 5, 8, 9, 1e, 1k, and 1m increased activity against HBV DNA replication with the SI values higher than 11. In particular, derivatives 1e and 1k exhibited the most potent inhibition on HBV DNA replication with the IC50 values of 0.026 mM (SI >70.8) and 0.045 mM (SI >36.0), respectively. The primary structure–activity relationships (SARs) of ET derivatives were summarized for exploring potent anti-HBV agents.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chang-An Geng, Xiao-Yan Huang, Yun-Bao Ma, Xue-Mei Zhang, Ji-Jun Chen,