| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369110 | Bioorganic & Medicinal Chemistry Letters | 2015 | 6 Pages |
Abstract
Based on in vitro studies of twelve newly-synthesized 1-acetamide-5-methoxy-2-oxindoles as 5-Ht7 receptor ligands, Structure Affinity Relationship (SAR) and Quantitative Structure Affinity Relationship model (QSAR) are provided. Also, a ligand-based pharmacophore model is proposed through molecular docking techniques and Nucleus Independent Chemical Shift DFT calculations (NICS).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Erik Díaz-Cervantes, Alejandro Islas-Jácome, Angel Rentería-Gómez, Juvencio Robles, Rocío Gámez-Montaño,