| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369111 | Bioorganic & Medicinal Chemistry Letters | 2015 | 6 Pages |
Abstract
Two new curcuminoids 1 and 2, and a new phenylbutenoid dimer 3, were isolated from Bangle (Zingiber purpureum). Their structures were determined on the basis of comprehensive spectroscopic data and their biogenetic pathway. Compounds 1 and 2 are the first example of curcumin coupled with phenylbutenoid. Compounds 1 and 2 promoted neurite outgrowth of NGF-mediated PC12 cells at concentrations ranging from 1 to 10 μM. In addition, compound 1 was found to accelerate the prevention of Aβ42 aggregation.
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Related Topics
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Organic Chemistry
Authors
Miwa Kubo, Minori Gima, Kohei Baba, Megumi Nakai, Kenichi Harada, Midori Suenaga, Yoichi Matsunaga, Eishin Kato, Shinya Hosoda, Yoshiyasu Fukuyama,