Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369132 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Cathepsin S is a potential target of autoimmune disease. A series of proline derived compounds were synthesized and evaluated as cathepsin S inhibitors. We discovered potent cathepsin S inhibitors through structure–activity relationship studies of proline analogues. In particular, compound 19-(S) showed promising in vitro/vivo pharmacological activities and properties as a selective cathepsin S inhibitor.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mira Kim, Jiyoung Jeon, Jiyeon Song, Kwee Hyun Suh, Young Hoon Kim, Kyung Hoon Min, Kwang-Ok Lee,