Article ID Journal Published Year Pages File Type
1369132 Bioorganic & Medicinal Chemistry Letters 2013 5 Pages PDF
Abstract

Cathepsin S is a potential target of autoimmune disease. A series of proline derived compounds were synthesized and evaluated as cathepsin S inhibitors. We discovered potent cathepsin S inhibitors through structure–activity relationship studies of proline analogues. In particular, compound 19-(S) showed promising in vitro/vivo pharmacological activities and properties as a selective cathepsin S inhibitor.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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