| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369151 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Our attempts to prepare indolyl acid (3), enroute to prenostodione (2), from phenyl-hydrazine following a reported procedure of Fischer-Indole synthesis rather lead to ethyl 2-(5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-3-yl)acetate as a major product, which underwent facile condensation with aldehydes to provide the pyrazolones. Intrigued by the opportunity for the diversity oriented synthesis of substituted pyrazolones, we have developed a facile one pot approach for pyrazolones and screened for antibacterial activity and, herein, results are reported.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Sivappa Rasapalli, Yingjun Fan, Menglong Yu, Christiaan Rees, John T. Harris, James A. Golen, Jerry P. Jasinski, Arnold L. Rheingold, Steven M. Kwasny, Timothy J. Opperman,