| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369157 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Conformation restriction of linear N-alkylanilide MK2 inhibitors to their E-conformer was developed. This strategy enabled rapid advance in identifying a series of potent non-ATP competitive inhibitors that exhibited cell based activity in anti-TNFα assay.
Graphical abstractConformation restriction of linear N-alkylanilide MK2 inhibitors to their E-conformer was developed. This strategy enabled rapid advance in identifying a series of potent non-ATP competitive inhibitors that exhibited cell based activity in anti-TNFα assay.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
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Authors
Dong Xiao, Anandan Palani, Xianhai Huang, Michael Sofolarides, Wei Zhou, Xiao Chen, Robert Aslanian, Zhuyan Guo, James Fossetta, Fang Tian, Prashant Trivedi, Peter Spacciapoli, Charles E. Whitehurst, Daniel Lundell,