| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369160 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
Many types of cancer, including glioma, melanoma, NSCLC, among others, are resistant to apoptosis induction and poorly responsive to current therapies with propaptotic agents. We describe a series of 2,3-disubstituted indoles, which display cytostatic rather than cytotoxic effects in cancer cells, and serve as a new chemical scaffold to develop anticancer agents capable of combating apoptosis-resistant cancers associated with dismal prognoses.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Igor V. Magedov, Florence Lefranc, Liliya V. Frolova, Laetitia Moreno Y. Banuls, Amanda S. Peretti, Snezna Rogelj, Véronique Mathieu, Robert Kiss, Alexander Kornienko,