Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369163 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
We report the design, synthesis, and biological evaluation of a new series of HDAC1 inhibitors using click chemistry. Compound 17 bearing a phenyl ring at meta-position was identified to show much better selectivity for HDAC1 over HDAC7 than SAHA. The compond 17 also showed better in vitro anticancer activities against several cancer cell lines than that of SAHA. This work could serve as a foundation for further exploration of selective HDAC inhibitors using the compound 17 molecular scaffold.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qiao Sun, Yiwu Yao, Chunping Liu, Hua Li, Hequan Yao, Xiaowen Xue, Jinsong Liu, Zhengchao Tu, Sheng Jiang,