| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369175 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
High throughput screening identified the pyrazole-4-acetic acid substructure as CRTh2 receptor antagonists. Optimisation of the compounds uncovered a tight SAR but also identified some low nanomolar inhibitors.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Miriam Andrés, Mónica Bravo, Maria Antonia Buil, Marta Calbet, Jordi Castro, Teresa Domènech, Peter Eichhorn, Manel Ferrer, Elena Gómez, Martin D. Lehner, Imma Moreno, Richard S. Roberts, Sara Sevilla,