Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369176 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Ribonucleoside phosphonate analogues containing 2′-α-fluoro modifications were synthesized and their potency evaluated against HCV RNA polymerase. The diphosphophosphonate (triphosphate equivalent) adenine and cytidine analogues displayed potent inhibition of the HCV polymerase in the range of 1.9–2.1 μM, but only modest cell-based activity in the HCV replicon. Pro-drugs of the parent nucleoside phosphonates improved the cell-based activity.
Graphical abstractRibonucleoside phosphonate analogues containing 2′-α-fluoro modifications were synthesized and their potency evaluated against HCV RNA polymerase.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jay P. Parrish, Sharon K. Lee, Constantine G. Boojamra, Hon Hui, Darius Babusis, Brandon Brown, I-hung Shih, Joy Y. Feng, Adrian S. Ray, Richard L. Mackman,