| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369180 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Invertebrate γ-aminobutyric acid (GABA)-gated chloride channels (GABACls) and glutamate-gated chloride channels (GluCls), which function as inhibitory neurotransmitter receptors, are important targets of insecticides and antiparasitic agents. The antagonism of GABACls and GluCls by 4-isobutyl-3-isopropylbicyclophosphorothionate (PS-14) was examined in cultured cockroach and rat neurons using a whole-cell patch-clamp method. The results indicated that PS-14 selectively blocks cockroach GABACls relative to cockroach GluCls and rat GABACls. PS-14 represents a useful probe for the study of insect GABA receptors.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuki Akiyoshi, Xiu-Lian Ju, Shogo Furutani, Kazuhiko Matsuda, Yoshihisa Ozoe,