Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369184 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
The synthesis of new ribo and 2′-β-C-methyl ribo Janus type nucleosides J-AA, J-AG and J-AU is reported along with their ability to block HCV and HIV replication. Their toxicity was also assessed in Huh7, human lymphocytes, CEM and Vero cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Longhu Zhou, Franck Amblard, Hongwang Zhang, Tamara R. McBrayer, Mervi A. Detorio, Tony Whitaker, Steven J. Coats, Raymond F. Schinazi,