Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369194 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
We report here the design, synthesis, and in vitro characterization of new opioid peptides featuring a 4-anilidopiperidine moiety. Despite the fact that the chemical structures of fentanyl surrogates have been found suboptimal per se for the opioid activity, the corresponding conjugates with opioid peptides displayed potent opioid activity. These studies shed an instructive light on the strategies and potential therapeutic values of anchoring the 4-anilidopiperidine scaffold to different classes of opioid peptides.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ravil R. Petrov, Yeon Sun Lee, Ruben S. Vardanyan, Lu Liu, Shou-wu Ma, Peg Davis, Josephine Lai, Frank Porreca, Todd W. Vanderah, Victor J. Hruby,