Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369198 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
A novel series of 10-hydroxyl ketolide derivatives were synthesized, during which a distinctive intermediate, 3-O-descladinosyl-3-oxo-11-deoxy-10,11-epoxy-6-O-methylerythromycin A, was obtained from 6-O-methylerythromycin A. The structure and stereochemistry of this novel structure were confirmed via NMR and X-ray crystallography. Moreover, antibacterial evaluations were established in order to assess our modifications and acquire a deep understanding of the ketolides’ structure–activity relationship (SAR).
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jie-Wei Jiang, Ying Sun, Ying Nie, Hui-Jing Zhi, Xiao-Jin Zhang, Xiang Li, Hao-Peng Sun, Qi-Dong You,