Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369200 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Compounds 1–25 showed varying degree of antileishmanial activities with IC50 values ranging between 1.95 and 88.56 μM. Compounds 2, 10, and 11 (IC50 = 3.29 ± 0.07 μM, 1.95 ± 0.04 μM, and 2.49 ± 0.03 μM, respectively) were found to be more active than standard pentamidine (IC50 = 5.09 ± 0.04 μM). Compounds 7 (IC50 = 7.64 ± 0.1 μM), 8 (IC50 = 13.17 ± 0.46 μM), 18 (IC50 = 13.15 ± 0.02 μM), and 24 (IC50 = 15.65 ± 0.41 μM) exhibited good activities. Compounds 1, 3, 4, 5, 9, 12, 15, 18, and 19 were found to be moderately active. Compounds 13, 14, 16, 17, 20–25 showed weak activities with IC50 values ranging between 57 and 88 μM.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Muhammad Taha, Mohd Syukri Baharudin, Nor Hadiani Ismail, Khalid Mohammed Khan, Faridahanim Mohd Jaafar, Samreen, Salman Siddiqui, M. Iqbal Choudhary,