| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369266 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Two new antiinflammatory macrolides, lobophorins A and B (1 and 2), have been isolated from fermentation broths of a marine bacterium isolated from the surface the Caribbean brown alga Lobophora variegata (Dictyotales). The new compounds, distantly related to antibiotics of the kijanimicin class, are potent inhibitors of topical PMA-induced edema in the mouse ear assay when administered either topically or IP.
The structures of two new anti-inflammatory macrolides, lobophorins A and B (1, 2), have been assigned by combined chemical and spectroscopic means. The compounds show activity similar to indomethacin and are active in an in vivo animal model.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhi-Dong Jiang, Paul R. Jensen, William Fenical,